Poe's amateur detective, C. Auguste Dupin, takes an interest in the murder in Paris of two women. It was terribly brutal but difficult to categorize; there appeared to be no robbery or sexual assault, no obvious reason for the crimes. The newspapers carried sensational headlines. Dupin gets involved because the man arrested for the crimes, Monsieur Le Bon, had previously done him a favour. It becomes a challenge to Dupin.
When Hercule Poirot and his associate Arthur Hastings arrive in the French village of Merlinville-sur-Mer to meet their client Paul Renauld, they learn from the police that he has been found that morning stabbed in the back with a letter opener and left in a newly-dug grave adjacent to a local golf course.
A serial murderer known only by a grotesquely apt nickname—Buffalo Bill—is stalking women. He has a purpose, but no one can fathom it, for the bodies are discovered in different states. Clarice Starling, a young trainee at the FBI Academy, is surprised to be summoned by Jack Crawford, chief of the Bureau's Behavioral Science section. Her assignment: to interview Dr. Hannibal Lecter—Hannibal the Cannibal—who is kept under close watch in the Baltimore State Hospital for the Criminally Insane.